Arguing that we ought to look to psychedelic aesthetics of the 1960s in relation to current crises in liberal democracy, this book emphasizes the intersection of European thought and the psychedelic. The first half of the book focuses on philosophical influences of Herbert Marcuse and Antonin Artaud, while the second half shifts toward literary and theoretical influences of Aldous Huxley on psychedelic aesthetics. Framed within an emergent discourse of political theology, it suggests that taking a postsecular approach to psychedelic aesthetics (...) helps us understand deeper connections between aesthetics and politics. (shrink)

In Alan Cameron's long-awaited and epoch-making studyThe Last Pagans of Rome, a typically erudite and stimulating chapter is devoted to the anonymous poem generally known today asCarmen contra paganos(CCP), written in the late fourth or (some have argued) early fifth century. This poem (of 122 lines)—of which the text is still in many places uncertain, in spite of a wealth of critical attention from the time when it was brought fully to light by Delisle in 1867 to the present day—is (...) a blistering invective against worshippers of the traditional gods and their practices, and against one person in particular, whose identity has been much debated. Cameron has brought forward a battery of strong arguments, many of them new, against the claims of Virius Nicomachus Flavianus, for a long time the front runner, whose name used to be given confidently in the poem's title, and, like Ellis and Cracco Ruggini, has strongly championed the claims of Vettius Agorius Praetextatus, the grandee who was consul designate for the year 385 but did not live to take up the office. (shrink)

In his panegyric of Avitus, his father-in-law, the poet Sidonius gives a vivid and often detailed picture of the career of the future emperor from his boyhood until he gained the supreme power in the West in the year 455, which he owed to his ability and accomplishments in warfare, diplomacy and administration. He also enjoyed strong support from both Goths and Gauls, and his repeated success in managing the volatility and the aspirations of the Goths is a major theme. (...) This short note seeks to contribute to the understanding of his emergence as Augustus by proposing a new interpretation of a pivotal passage (lines 519–24), quoted below. The context can be briefly given. Sidonius has painted a graphic picture of the reaction among the Goths to the news of the Vandal capture of Rome in the year 455 (lines 441–57). In the ensuing assembly of Gothic elders Avitus (who happens to be with them at Toulouse at this moment) gives a speech that vigorously praises peace (lines 458–86), and this is favourably received. There follows a speech from the Gothic king, Theoderic II, in which he puts his own strong case for an agreement between Goths and Gauls, and seeks to persuade Avitus to fill the vacuum in Rome and Italy caused by the recent death of the emperor Petronius Maximus and take the name of Augustus (lines 489–518). (shrink)

A corrected and extensively annotated version of the sole meeting between two of the most important figures in twentieth-century intellectual life.

IntroductionCognitive impairment is a highly prevalent non-motor feature of Parkinson’s disease. A better understanding of the underlying pathophysiology may help in identifying therapeutic targets to prevent or treat dementia. This study sought to identify metabolic alterations in the prefrontal cortex, a key region for cognitive functioning that has been implicated in cognitive dysfunction in PD.MethodsProton Magnetic Resonance Spectroscopy was used to investigate metabolic changes in the PFC of a cohort of cognitively normal individuals without PD, as well as PD participants (...) with either normal cognition, mild cognitive impairment, or dementia. Ratios to Creatine resonance were obtained for glutamate, glutamine and glutamate combined, N-acetylaspartate, myoinositol, and total choline, and correlated with cognitive scores across multiple domains administered to the PD participants only.ResultsWhen individuals retain cognitive capabilities, the presence of Parkinson’s disease does not create metabolic disturbances in the PFC. However, when cognitive symptoms are present, PFC Glu/Cre ratios decrease with significant differences between the PD-NC and PPD groups. In addition, Glu/Cre ratios and memory scores were marginally associated, but not after Bonferroni correction.ConclusionThese preliminary findings indicate that fluctuations in prefrontal glutamate may constitute a biomarker for the progression of cognitive impairments in PD. We caution for larger MRS investigations of carefully defined PD groups. (shrink)

Boarding school is a major educational option for many students (e.g., students living in remote areas, or whose parents are working interstate or overseas, etc.). This study explored the motivation, engagement, and achievement of boarding and day students who are educated in the same classrooms and receive the same syllabus and instruction from the same teachers (thus a powerful research design to enable unique comparisons). Among 2,803 students (boardingn= 481; dayn= 2,322) from 6 Australian high schools and controlling for background (...) attributes and personality, we found predominant parity between boarding and day students in their motivation, engagement, and achievement. We also found that classroom-average motivation, engagement, and achievement was not significantly affected by the number of boarders (relative to day students) in the classroom. In addition, the effects of boarding were generally not moderated by students’ background or personality attributes. We conclude that boarders have academic opportunities and outcomes that are comparable to their day student counterparts. Implications for students, teachers, and parents are discussed. (shrink)

The scientific, ethical, and policy issues raised by research involving the engraftment of human neural stem cells into the brains of nonhuman primates are explored by an interdisciplinary working group in this Policy Forum. The authors consider the possibility that this research might alter the cognitive capacities of recipient great apes and monkeys, with potential significance for their moral status.

Because the main difference between combinatory weak equality and λβ-equality is that the rule \begin{equation*}\tag{\xi} X = Y \vdash \lambda x.X = \lambda x.Y\end{equation*} is valid for the latter but not the former, it is easy to assume that another way of defining combinatory β-equality is to add rule (ξ) to the postulates for weak equality. However, to make this true, one must choose the definition of combinatory abstraction in (ξ) very carefully. If one tries to use one of the (...) more common abstraction algorithms, the result will be an equality, = ξ , that is either equivalent to βη-equality (and so strictly stronger than β-equality) or else strictly weaker than β-equality. This paper will study the relations = ξ for several commonly used abstraction algorithms, distinguish between them, and axiomatize them. (shrink)

BackgroundKnowledge about the psychosocial experiences of sick-listed workers in the first months of sick leave is sparse even though early interventions are recommended. The aim of this study was to explore psychosocial experiences of being on sick leave and thoughts about returning to work after 8–12 weeks of sickness absence.MethodsSixteen individuals at 9–13 weeks of sick leave participated in semi-structured individual interviews. Data was analyzed through Giorgi’s descriptive phenomenological method.ResultsThree themes emerged: energy depleted, losing normal life, searching for a solution. (...) A combination of health, work, and family challenges contributed to being drained of energy, which affected both work- and non-work roles. Being on sick leave led to a loss of social arenas and their identity as a contributing member of society. Participants required assistance to find solutions toward returning to work.ConclusionEven in this early stage of long-term sick leave, sick listed workers faced complex challenges in multiple domains. Continuing sick leave was experienced as necessary but may challenge personal identity and social life. Those not finding solutions may benefit from additional early follow-up that examine work-related, social and personal factors that influence return to work. (shrink)

This report documents the program and the outcomes of Dagstuhl Seminar 21381 "Conversational Agent as Trustworthy Autonomous System ". First, we present the abstracts of the talks delivered by the Seminar’s attendees. Then we report on the origin and process of our six breakout groups. For each group, we describe its contributors, goals and key questions, key insights, and future research. The themes of the groups were derived from a pre-Seminar survey, which also led to a list of suggested readings (...) for the topic of trust in conversational agents. The list is included in this report for references. (shrink)

This essay examines the recurrence of New Age typologies in different ages and different cultures. The archetype is defined as the revolutionary idealist who is intellectual, declassé, an experimenter and a seeker after truth. The essay then proceeds to compare and contrast key intellectual and spiritual figures to establish the extent to which they conform to the archetype: Percy Shelley and Otto Gross, Mahatma Gandhi and St. Francis of Assisi. It concludes with an examination of the career and ideas of (...) John Middleton Murry and argues the case for him to be seen as a New Age archetype — the New Age man of letters. (shrink)

Two recent studies by Parisi et al.1 and Ranz et al.,2 catalogue sex differences in gene expression across the whole genome of the fruit fly Drosophila melanogaster. Both report striking associations of sex‐biased gene expression with the X chromosome. Genes with male‐biased expression are depauperate on the X chromosome, whereas genes with female‐biased expression show weaker evidence of being in excess. A number of evolutionary hypotheses for the expulsion or exclusion of male‐biased genes from the X chromosome have been suggested. (...) None is entirely consistent with the available evidence. BioEssays 25:739–741, 2003. © 2003 Wiley Periodicals, Inc. (shrink)

In this article we respond to arguments from William Hasker and David Kyle Johnson that free will is incompatible with both divine foreknowledge and eternalism (what we refer to as isotemporalism). In particular, we sketch an Anselmian account of time and freedom, briefly defend the view against Hasker's critique, and then respond in more depth to Johnson's claim that Anselmian freedom is incompatible with free will because it entails that our actions are 'ontologically necessary'. In defending Anselmian freedom we argue (...) that our ordinary intuitions do not support Johnson's case and that Anselmian freedom is compatible with deliberation. (shrink)

Em busca da relação profícua entre Psicanálise e História, procura-se, neste artigo avaliar como Carlo Ginzburg, em sua trajetória intelectual e acadêmica, discutiu Freud e a Psicanálise à luz da Micro-História. Para tanto, a obra de Ginzburg Mitos, emblemas, sinais: morfologia e história tornou-se um manancial para esta busca. Nos capítulos Sinais: raízes de um paradigma indiciário e, principalmente, Freud, o homem dos lobos e os lobisomens, Ginzburg discute criticamente as interpretações de Freud sobre o seu caso clínico mais importante, (...) um paciente russo de nome Serguei Constantinovitch Pankejeff, conhecido como O Homem dos Lobos. Ginzburg não deixa de reconhecer a magnitude da obra de Freud, mas aponta suas limitações como não considerar suficientemente a formação cultural de seu paciente e dar um enfoque maior a individuação. Ginzburg permitiu, ainda, demonstrar em sua obra a importância da Psicanálise na elaboração do conceito fundamental à MicroHistória, o paradigma indiciário. (shrink)